In the 10-year history of Stem Cell Reports, the journal has published nearly 2,000 papers across the spectrum of stem cell research, including the topic of cellular reprogramming.
Cellular reprogramming has been around for decades but was catapulted into the scientific spotlight with the discovery that a combinatorial code of transcription factors could convert somatic cells to pluripotent stem cells. Recently, this approach has been applied towards directly reprogramming one somatic cell type into another, bypassing the pluripotent stage. This approach has been used in vitro and in vivo to convert cells into muscle, neurons, and cardiac cells, among other cell types. As part of Stem Cell Reports’ 10-year anniversary celebration, we are exploring the latest approaches and applications of in vitro and in vivo reprogramming in different systems and tissues.