ISSCR News
New Podcast Episode. PSC Developmental Bias: The Mechanism and the Variation in Human Neural Development
The guests on this episode of The Stem Cell Report studied functional variation in human PSC lines as they progress through neurectoderm versus mesendoderm lineages and fore- versus hind-brain development. They will discuss the origin and consequences of inter-individual variation in the early events orchestrating human neural development, the extent to which such variation might impact on adult health and disease, and how it might be exploited in stem cell therapy.
Scientists Aim to Decode the Genetic Roots of Mental Illness on a Large Scale
Neurodevelopmental and psychiatric disorders (NPD) including schizophrenia, bipolar disorder, autism, and depression are detrimental to individuals, their families and society as a whole, and in many cases still lack effective treatments. It’s becoming more and more clear that genetic mutations in certain genes can increase the likelihood of developing NPD, and several hundreds of those “risk genes” have been identified to date, but their role related to NPD remains a mystery.
New Podcast Episode. Aging, Stem Cells, and Biological Clocks
In this episode of The Stem Cell Report, Martin Pera is joined by Konrad Hochedlinger, PhD, and Rebecca Gorelov, PhD, to discuss their recent publication in Stem Cell Reports. Epigenetic clocks are promising biomarkers of aging, but little is known about their cellular basis.
Reading Your Biological Age in Your Blood or Saliva? It’s Not as Simple as That
How old are you, really? Your chronological age is the number of years you have been alive. Your biological age is how old your cells are which scientists believe may better assess one’s age-related health and disease risk. A recent study by Konrad Hochedlinger, Rebecca Gorelov and colleagues from Harvard Medical School and Massachusetts General Hospital, USA, aims to shed light on this question, asking how the presence of stem cells within a given tissue or organ impacts its epigenetic clock.
New Podcast Episode. Evaluating the Expanding Models of Brain Disease
In this episode of The Stem Cell Report, our guests review the use of models of neurodevelopment to understand neuropsychiatric diseases, focusing on Alzheimer’s and Parkinson’s disease, epilepsy, Down syndrome, and schizophrenia and provide critical appraisal of the impact of human-rodent xenografting approaches for advancing our understanding of those diseases and brain development.
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