New Guidance from ISSCR Ethics Committee Clarifies Scientific Justification for Stem Cell and Embryo Research

In an article published today in Stem Cell Reports complements the 2021 ISSCR Guidelines for Stem Cell Research and Clinical Translation, providing essential clarification on what constitutes “adequate and appropriate scientific justification” in studies involving human pluripotent stem cells, embryos, and related research.

As research in areas like extended in vitro embryo culture, in vitro gametogenesis, organoid development, and embryo modeling progresses rapidly, so does public interest and ethical scrutiny. The article offers practical guidance for regulators, review boards, and investigators to support thorough, transparent, and ethically responsible research practices.

The article emphasizes the importance of rigorous scientific and ethical review before research begins. Further, it reinforces that projects involving human embryonic cells, embryos, or gametes must demonstrate clear scientific merit and be reviewed through specialized oversight processes that involve experts in both science and ethics.

This timely contribution from ISSCR Ethics Committee members aims to support the responsible advancement of early human development research while ensuring public trust and adherence to high ethical standards.

Read the article: What does “appropriate scientific justification” mean for the review of human pluripotent stem cell, embryo, and related research?